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WHAT IS OSTEOARTHRITIS (OA)?
- Osteoarthritis (OA) is known as the most common chronic disease of the cartilage. As the cartilage breaks down due to wear-and-tear and/or mechanical stress, it causes swelling, pain and inflammation, leading to extracellular matrix (ECM) loss¹ .
- Knee osteoarthritis (KOA) is a progressive joint disease that often involves intra- and per articular structures² and is considered pathology characterized by articular cartilage lesions, synovitis, subchondral sclerosis, and osteophytes³.
- Knee osteoarthritis (OA) is most often a slowly progressive joint disorder characterized by cartilage degeneration and inflammation⁴. Knee OA commonly results in knee pain and decreases patients’ mobility (e.g. walking and stair climbing)⁵.
- The pain of osteoarthritis is usually related to activity. For osteoarthritis of the knee (Fig. 1), activities such as climbing stairs, getting out of a chair, and walking long distances bring on pain. Morning stiffness usually lasts less than 30 minutes.⁶ Patients often note that their knees “give way,” a so-called instability symptom.